A PROTEIN-PROTEIN INTERACTION MAP REVEALS THAT THE COXIELLA BURNETII EFFECTOR CIRB INHIBITS HOST PROTEASOME ACTIVITY.

A protein-protein interaction map reveals that the Coxiella burnetii effector CirB inhibits host proteasome activity.

Coxiella burnetii is the etiological agent of the zoonotic disease Q fever, which is featured by its ability to replicate in acid vacuoles resembling the lysosomal network.One key virulence determinant of C.burnetii is the Dot/Icm system that transfers more than 150 effector proteins into host cells.These effectors function to construct the lysosom

read more

Percutaneous transcatheter closure of a descending aorta to vertebral venous plexus fistula using an Amplatzer Vascular Plug 2: a case report

A descending aorta to USA Map Wooden Puzzle vertebral venous plexus fistula is an extremely rare form of arteriovenous fistula.A 10-month-old infant was referred to the hospital for evaluation of a murmur.On examination, a continuous murmur was heard in the entire back.Transthoracic echocardiography revealed left heart chamber dilatation in the pre

read more


HISTORICAL FAILURE OR POLITICAL REALISM?

After nearly 65 years of the Hungarian 1956 Revolution, several questions remained unanswered, mainly concerning the international responses to the Revolution and the Power Core Combiners brutal suppression of the revolt.The article examines the possibilities and the limitations of the international organization when two member states violate the C

read more